BioSerf is our new, experimental, fully automated, ab initio homology modelling pipeline available via the World Wide Web or as an XML driven webservice (manuscript in preparation). BioSerf uses a selection of algorithms including PSI-BLAST, PSIPRED and pGenTHREADER to attempt to select appropriate template structures for homology modelling. Where a suitable template or templates can not be found BioSerf uses Modeller to build a model. Where no suitable template structure can be found FRAGFOLD is used to build a model (see figure below). As this service uses Modeller, a valid modeller licence key is required to submit sequences to the service.